Cool Tool: Slick Run

Slick Run could literally really save you hours of dragging your mouse to program shortcuts!

Quoting the author:

SlickRun is a free floating command line utility for Windows. SlickRun gives you almost instant access to any program or website. SlickRun allows you to create command aliases (known as MagicWords), so C:\Program Files\Outlook Express\msimn.exe becomes MAIL.

Enter a web URL into SlickRun and it will launch your browser and navigate to the specified address. Run multiple programs in a few keystrokes, jot a note, look up a definition... SlickRun is the most natural way to interact with your computer.